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Volume 55, Number 3, June 2009

REVIEW

Sex Differences of Drug-metabolizing Enzyme: Female Predominant Expression of Human and Mouse Cytochrome P450 3A Isoforms
[Abstract], [Full-Text PDF (280 kB)]
Tsutomu Sakuma, Yuki Kawasaki, Kanokwan Jarukamjorn, and Nobuo Nemoto.....325

MINIREVIEW

Side Effects of Molecularly Targeted Drugs and Their Molecular Mechanisms
[Abstract], [Full-Text PDF (128 kB)]
Reiko Takemura and Yoko Hamamoto.....338

Oxidative Stress-Dependent Cellular Toxicity and Cytoprotection during Exposure to 9, 10-phenanthraquinone, a Component of Diesel Exhaust Particles
[Abstract], [Full-Text PDF (152 kB)]
Keiko Taguchi.....347

REGULAR ARTICLES

Subacute (28 day) Toxicity of Surfactin C, a Lipopeptide Produced by Bacillus subtilis, in Rats
[Abstract], [Full-Text PDF (1.30 MB)]
Youn-Hwan Hwang, Myoung-Seok Kim, In-Bae Song, Byung-Kwon Park, Jong-Hwan Lim, Seung-Chun Park, and Hyo-In Yun.....351

Hepatic Cytochrome P450 2E1 Level Rather Than Cecal Condition Contributes to Induction of Early Stage of the Alcoholic Liver Damage in Rats
[Abstract], [Full-Text PDF (236 kB)]
Naoto Hashimoto, Hiroyuki Sekiguchi, Akira Masunaka, Katsuichi Saito, Hiroaki Yamauchi, Takahiro Noda, Kyu-Ho Han, and Michihiro Fukushima.....356

Aquatic Fate of Sunscreen Agents Octyl-4-methoxycinnamate and Octyl-4-dimethylaminobenzoate in Model Swimming Pools and the Mutagenic Assays of Their Chlorination Byproducts
[Abstract], [Full-Text PDF (536 kB)]
Mariko Nakajima, Tsuyoshi Kawakami, Tatsuhiro Niino, Yasuo Takahashi, and Sukeo Onodera.....363

Isolation of N-acetylneuraminic Acid and N-glycolylneuraminic Acid from Pleurocybella porrigens
[Abstract], [Full-Text PDF (200 kB)]
Takanobu Takata, Tatsuya Hasegawa, Takanori Tatsuno, Junichiro Date, Yasuhito Ishigaki, Yuka Nakamura, Naohisa Tomosugi, Fumihide Takano, and Tomihisa Ohta.....373

Effects of Di(2-ethylhexyl) Phthalate on Regulation of Steroidogenesis or Spermatogenesis in Testes of Sprague-Dawley Rats
[Abstract], [Full-Text PDF (836 kB)]
Young Jun Lee, Ena Lee, Tae Hyung Kim, Jae Seok Choi, Jaewon Lee, Ki Kyung Jung, Seung Jun Kwack, Kyu Bong Kim, Tae Seok Kang, Soon Young Han, Byung Mu Lee, and Hyung Sik Kim.....380

Prostaglandin E2 Increases the Expression of B-Type Natriuretic Peptide Receptor through EP1 Receptor, Ca2+ Mobilization and Protein Kinase C Signaling Pathway in Rat Calvarial Osteoblasts
[Abstract], [Full-Text PDF (320 kB)]
Hiroyuki Kaneki, Maki Kurokawa-Nagai, Yuri Sugano, Gaku Ishi-i, Minoru Kurokawa, and Hayao Ide.....389

17β-Estradiol Enhances Interleukin-18 mRNA Expression after Sensitization of Mice with Contact Hypersensitivity
[Abstract], [Full-Text PDF (6.03 MB)]
Fumitoshi Sakazaki, Masahiro Fujiyama, Hitoshi Ueno, Hisamitsu Nagase, and Katsuhiko Nakamuro.....396

High K+-induced Increase in Extracellular Glutamate in Zinc Deficiency and Endogenous Zinc Action
[Abstract], [Full-Text PDF (936 kB)]
Atsushi Takeda, Hiromasa Itoh, Haruna Tamano, and Naoto Oku.....405

Dysregulation of Lipid and Cholesterol Metabolism in High Fat Diet Fed Hyperlipidemic Rats: Protective Effect of Sida rhomboidea. roxb Leaf Extract
[Abstract], [Full-Text PDF (120 kB)]
Menaka Thounaojam, Ravirajsinh Jadeja, Ansarullah, Ranjitsinh Devkar, and Ramachandran AV.....413

Nicotine, Tar, and Mutagenicity of Mainstream Smoke Generated by Machine Smoking with International Organization for Standardization and Health Canada Intense Regimens of Major Japanese Cigarette Brands
[Abstract], [Full-Text PDF (204 kB)]
Osamu Endo, Mariko Matsumoto, Yohei Inaba, Kazutoshi Sugita, Daisuke Nakajima, Sumio Goto, Hiromitsu Ogata, and Gen Suzuki.....421

Potential of a Novel Safety Evaluation of Nanomaterials Using a Proteomic Approach
[Abstract], [Full-Text PDF (484 kB)]
Hisao Haniu, Yoshikazu Matsuda, and Kenji Takeuchi.....428

RESEARCH LETTERS

Prospective Study to Assess the Optimal Blood Concentration of Tacrolimus in Japanese Patients with Rheumatoid Arthritis
[Abstract], [Full-Text PDF (156 kB)]
Hitoshi Kawazoe, Hiroaki Dobashi, Tomohiro Kameda, Kentaro Susaki, Katuharu Kittaka, Michiaki Tokuda, Noriyasu Fukuoka, Toshihiko Ishida, Yoshiharu Takiguchi, and Hitoshi Houchi.....435

(+)-Catechin with Cu2+ Induces Protein Modifications via Reactive Oxygen Species-independent Pathway
[Abstract], [Full-Text PDF (148 kB)]
Maiko Kaku and Kazuo Nakagawa.....441

Ferrous Ferric Chloride Stimulates the Proliferation of Human Skin Keratinocytes, Melanocytes, and Fibroblasts in Culture
[Abstract], [Full-Text PDF (3.11 MB)]
Tomohisa Hirobe.....447

The Expression of Antimicrobial Peptide Lysozyme is Increased by Treatment with Silver Nanoparticle (Atomyball S®) in Mammalian Epithelial Cells
[Abstract], [Full-Text PDF (412 kB)]
Mary Ann Suico, Atsushi Tanaka, Tsuyoshi Shuto, and Hirofumi Kai.....456

RAPID COMMUNICATIONS

Naringin Suppresses Osteoclast Formation and Enhances Bone Mass in Mice
[Abstract], [Full-Text PDF (2.12 MB)]
Michiko Hirata, Chiho Matsumoto, Morichika Takita, Chisato Miyaura, and Masaki Inada.....463

Proteolytic Release of Latent Transforming Growth Factor-β (TGF-β) Binding Protein-1 (LTBP-1) Fragment in Wound Healing
[Abstract], [Full-Text PDF (976 kB)]
Koji Mizuno, Hiroshi Wachi, Zenzo Isogai, Masahiko Yoneda, Satoshi Fujii, Ken Watanabe, and Yoshiyuki Seyama.....468