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J.Health Sci., 55(3), 347-350, 2009
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Oxidative Stress-Dependent Cellular Toxicity and Cytoprotection during Exposure to 9,10-phenanthraquinone, a Component of Diesel Exhaust Particles
Keiko Taguchi
Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, 2-1 Seiryo-cho, Aoba, Sendai 980-8575, Japan
Quinones are ubiquitously present in the environment. This review summarizes the cellular toxicity of 9,10-phenanthraquinone (9,10-PQ), a component of diesel exhaust particles, and the cytoprotective mechanism of the nuclear factor erythroid 2-related factor 2 (Nrf2)/Kelch-like ECH-associated protein 1 (Keap1) system against oxidative stress exerted by 9,10-PQ.
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