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J.Health Sci., 57(5), 432-435, 2011
-Research Letter-
Citidine-5-diphosphocholine Ameliorates the Impairment of Spatial Memory Induced by Scopolamine
Kotaro Takasaki,*, a Kenichi Mishima,a
Masahiko Morita,b Koji Morishita,b
Ai Nogami,a Yuya Sakamoto,a
Masaki Nagao,a Kaori Kubota,a
Shutaro Katsurabayashi,a Michihiro Fujiwara,a
and Katsunori Iwasakia
aDepartment of Neuropharmacology, Faculty of Pharmaceutical Science, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan and
bHealthcare Products Development Center, KYOWA HAKKO BIO CO., LTD., 2 Miyukigaoka, Tsukuba 305-0841, Japan
The memory enhancing effects of orally administered citidine-5-diphosphocholine or citicoline (CDP-choline) on memory impairment without neuronal cell death are still unknown. We investigated the effects of CDP-choline on memory disturbance induced by scopolamine using an eight-armed radial maze task. Orally repeated administration of CDP-choline or histidine significantly restored the errors impaired by scopolamine. CDP-choline may increase hippocampal and neocortical acetylcholine levels. These results suggest that CDP-choline has ameliorative effects on the impairment of spatial memory induced not only by neuronal cell death but also by impaired cholinergic signal.
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