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J.Health Sci., 57(3), 289-292, 2011
-Research Letter-
Protective Effect of Cimicifuga heracleifolia Ethanol Extract and Its Constituents against Gastric Injury
Mijeong Kim,a In Young Hwang,b
Je-Hyuk Lee,c Kun Ho Son,d
Choon-Sik Jeong,b and Joohee Jungb, 1, *
aSchool of Public, Seoul National University, 1-Gwanak, Gwanak, Seoul 151-742, Korea,
bCollege of Pharmacy and
cPlant Resources Research Institute, Duksung Women's University, 419 Ssangmoon, Dobong, Seoul 132-714, Korea and
dDepartment of Food Science and Nutrition, Andong National University, 1375-Gyeongdong, Andong, Gyeongbuk 760-749, Korea
1Present address: Institute for Innovative Cancer Research, Asan Medical Center, 86-Asanbyeonwon-gil, Songpa, Seoul 138-736, Korea
Cimicifuga heracleifolia (CH) ethanol extract and its constituents such as ferulic acid, caffeic acid, 24-epi-7,8-didehydrocimigenol-3-xyloside, and 23-O-acetylshengmanol 3-xyloside were investigated for their abilities to prevent gastric injury. To elucidate their gastric-protective effects, we assessed 1,1-diphenyl-2-picrylhydrazyl radical-radical scavenging activity and inhibition of Helicobacter pylori (H. pylori) and gastric cancer cells. Ferulic acid and caffeic acid exhibited higher free radical scavenging activity than other constituents and inhibited the colonization of H. pylori effectively. Furthermore, 24-epi-7,8-didehydrocimigenol-3-xyloside and 23-O-acetylshengmanol-3-xyloside showed cytotoxicity in gastric cancer cells (SNU638 and AGS cells). These results suggest the novel activities of CH ethanol extract and its constituents. CH ethanol extract and its constituents could be utilized for the treatment and/or prevention of gastric injury.
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