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J.Health Sci., 57(2), 210-214, 2011
-Rapid Communication-
Therapeutic Effects of Ca2+ on Peritoneal Dissemination of Gastric Carcinoma in Vivo
Kazuki Tatsumi, Hideaki Ichihara,
Yuji Komizu, Koichi Goto,
and Ryuichi Ueoka*
Division of Applied Life Science, Graduate School of Engineering, Sojo University, 4-22-1 Ikeda, Kumamoto 860-0082, Japan
It is well known that oral calcium supplementation has inhibited the gastric carcinogenesis in animals treated with chemical carcinogen and sodium chloride. However, the therapeutic effects of calcium ion (Ca2+) for peritoneal dissemination of gastric carcinoma in vivo remain unknown. Here, we showed that Ca2+ could be effective for inhibiting the peritoneal metastasis of gastric carcinoma MKN-45 cells along with apoptosis in vivo. Significantly prolonged survival was obtained for the peritoneal dissemination mouse models of MKN-45 cells after the intraperitoneal injection (i.p.) of Ca2+. These results suggest that Ca2+ could be a new candidate i.p. drug against peritoneal dissemination of gastric cancer in human.
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