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J.Health Sci., 57(1), 82-85, 2011
-Research Letter-
Hypothermia after Reperfusion Suppresses Aggravation of Acute Brain Edema following Transient Forebrain Ischemia in Mice
Masaru Doshi,* Etsuka Higuchi,
and Yutaka Hirashima
Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Teikyo University, 1091-1 Suarashi, Midoriku, Sagamihara 252-5195, Japan
In our previous paper, we reported that spontaneous hypothermia (HT) during ischemia protects against delayed neuronal death in the hippocampus but not against acute brain edema following transient forebrain ischemia, which is induced by occlusion of the bilateral common carotid arteries (BCCA) in C57BL/6J mice. We here demonstrate that artificial HT after reperfusion (rHT) suppresses the aggravation of acute brain edema in the BCCA occlusion C57BL/6J mouse model. Our results suggest that mechanisms regulated by rHT are involved in the attenuation of acute brain edema after reperfusion in this model of cerebral ischemia.
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