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J.Health Sci., 56(6), 664-674, 2010
-Regular Article-
Cholinesterase-inhibiting Potentials of Amberlite XAD-2 Resin Extracts Collected from River and Drinking Waters in Northwest District of Chiba Prefecture, Japan
Ayako Kanno,a Iwaki Nishi,a
Tomohiro Kishi,a Tsuyoshi Kawakami,a, b
Yasuo Takahashi,a and Sukeo Onodera*, a
aFaculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba, 278-8501 Japan and
bDivision of Medical Devices, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-1501, Japan
Amberlite XAD-2 resin extracts of river and drinking water sampled in each month during the period from January to December 2008 from the Northwest district of Chiba Prefecture were investigated to characterize and determine their cholinesterase (ChE)-inhibiting potentials and pesticide levels. The XAD-2 extracts from river water collected during the mid-spring to mid-summer periods exhibited strong inhibition effect to horse serum ChE, reflecting the application of organophosphorus and carbamate pesticides to paddy fields. Gas chromatographicmass spectrometric (GC/MS) determinations of the XAD-2 extracts of the river water collected during spring to summer periods also showed to be comparatively high levels of agricultural chemicals, such as herbicides, insecticides and fungicides, as compared with those detected in the drinking water. Although a considerable reduction in the ChE-inhibiting potentials and in the GC/MS detectable compound levels was observed for the river water samples, it is particularly interest that ChE-inhibiting potentials still remained in the drinking water.
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