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J.Health Sci., 56(5), 589-597, 2010
-Regular Article-
Participation of Th17 and Treg Cells in Pediatric Bronchial Asthma
Yoshiki Yamamoto,a, b Takaharu Negoro,*, c
Akiko Wakagi,c Akane Hoshi,c
Alison H. Banham,d Giovanna Roncador,e
Haruyo Akiyama,c Takashi Tobe,f
Susumu Sunaga,a Yasuko Nakano,c
and Kazuo Itabashib
aDepartment of Pediatrics, Tokyo Metropolitan Health and Medical Treatment Corporation Ebara Hospital, 4-5-10 Higashiyukigaya, Ota-ku, Tokyo 145-0065, Japan,
bDepartment of Pediatrics, School of Medicine and
cDepartment of Pharmacogenomics, School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan,
dNuffield Department of Clinical Laboratory Sciences, University of Oxford, Level 4 Academic Block, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK,
eMonoclonal Antibodies Unit, Biotechnology Program, Centro Nacional de Investigaciones Oncolo'gicas (CNIO), C/Melchor Ferández Almagro, 3, E-28029, Madrid, Spain and
fCenter of Pharmaceutical Education, School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan
The immune response plays an important role in the development of allergic diseases. It is established that a complex network of various immunocytes such as Th2, non-Th2 (Th17), and regulatory T (Treg) participate in allergic reactions. In this study, we examined the frequencies of Th17 cells (IL-17-positive cells) and Treg cells (FOXP3-positive cells) in the peripheral blood and elucidated their participation in pediatric allergic diseases such as bronchial asthma and food allergies. Our study included 35 subjects, 27 with allergic diseases (19 with asthma and 8 with food allergies) and 8 were controls (without any allergic diseases); their age ranged from 1 to 13 years. The frequency of Th17 cells (IL-17-positive cells) among the CD4+T cells in the peripheral blood was 2.33±1.29% in patients with bronchial asthma, 1.53±1.34% in those with food allergies, and 1.50±0.809% in controls. These results indicated that only the patients with bronchial asthma had a trend towards a higher frequency of Th17 cells (p=0.1558). The ratio of Th17 cells to Treg cells did not show any statistical correlation among the patients with bronchial asthma. However, when we excluded the patients with a severe type of asthma, we could obtain an inverse trend between the ratio of Th17 cells to Treg cells (p=0.1655). This study suggested that Th17 cells and Treg cells participate in pediatric allergic reactions such as bronchial asthma.
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