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J.Health Sci., 56(3), 347-354, 2010
-Research Letter-
Lowering Effects of Allyl Isothiocyanate on the Number of Lymphocyte and Its Subsets in Rats
Kazuhiko Imaizumi,*, a Yuko Sakakibara,a
Hiromi Sasaki,a Shogo Sato,a
Yumi Takei,a Kaori Hiruma,a
Takamasa Ban,a Yu Kawashima,b
Jun Tanihata,c and Kaoru Tachiyashikid
aLaboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa 359-1192, Japan,
bSchool of Medicine, University of Yamanashi, 1110 Shimokatoh, Chuo, Yamanashi 409-3898, Japan,
cLaboratory of Rehabilitation Biomedical Sciences, Faculty of Human Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa 359-1192, Japan and
dDepartment of Living and Health Sciences, Graduate School of Education, Joetsu University of Education, 1 Yamayashiki, Joetsu 943-8512, Japan
The purpose of this study was to elucidate the effects of a main pungent component of wasabi, allyl isothiocyanate (AITC), on the number of lymphocytes, T-lymphocyte, B-lymphocyte and natural killer (NK) cells and plasma corticosterone concentrations in rats. AITC was given as either single dosage [20 mg/kg body weight per day; subcutaneous (s.c.) and oral] or as a daily dosage (10 mg and 20 mg/kg body weight per day; s.c.) for 4 days for the hourly and daily assessment of changes in the numbers of lymphocytes, respectively. A single s.c. injection or oral administration of AITC significantly reduced the number of lymphocytes at 4 hr to approximately 0.68 times, indicating that decreased effects of AITC on the number of lymphocytes are independent on the administration route. Administration of AITC for 4 days reduced dose-dependently the number of lymphocytes, and significantly reduced the number of T-lymphocyte and B-lymphocyte to 0.79 and 0.60 times, respectively. However, the number of NK cells did not change by AITC. Administration of AITC increased plasma corticosterone concentrations at 4 day of post s.c. injection to 5.4-6.0 times. These results suggest that AITC-mediated immunosuppresion is at least in part attributable to changes in the number and distribution of lymphocyte and its subsets.
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