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J.Health Sci., 56(3), 296-303, 2010
-Regular Article-
Neuroprotective Effect of Repeated Treatment with Hericium erinaceum in Mice Subjected to Middle Cerebral Artery Occlusion
Mai Hazekawa,a, b Aiko Kataoka,a
Kazuhide Hayakawa,a Takeshi Uchimasu,a
Riyo Furuta,a Keiichi Irie,a, c
Yoshiharu Akitake,a Miyako Yoshida,b, d
Toshihiro Fujioka,d Nobuaki Egashira,e
Ryozo Oishi,e Kenji Mishima,f
Kenichi Mishima,*, a, c Takahiro Uchida,b
Katunori Iwasaki,a, c and Michihiro Fujiwaraa
aDepartment of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Fukuoka 814-0180, Japan,
bDepartment of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Mukogawa Women's University, 11-68, Koshien Kyuban-cho, Nishinomiya 663-8179, Hyogo, Japan,
cAdvanced Materials Institute and
dDepartment of Instrumental Analysis, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1, Nanakuma, Fukuma, 814-0180, Fukuoka, Japan,
eDepartment of Pharmacy, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Fukuoka, Japan and
fDepartment of Chemical Engineering, Fukuoka University, 8-19-1, Nanakuma, Fukuoka 814-0180, Fukuoka, Japan
The neuroprotective effects of Hericium erinaceum (H. erinaceum) were studied in mice subjected to middle cerebral artery (MCA) occlusion. Infarct volumes were markedly reduced in mice receiving 14 days of H. erinaceum (300 mg/kg) treatment prior to 4-hr MCA occlusion. Moreover, 14-day pre-ischemic H. erinaceum treatment significantly increased the levels of nerve growth factor (NGF) in both the cortex and striatum of mice subjected to 4-hr MCA occlusion. However, pre-ischemic H. erinaceum treatment had no effect on cerebral blood flow (CBF) in the cortex of mice subjected to MCA occlusion. Treatment with H. erinaceum for 1 day prior to MCA occlusion-induced ischemia had no effect on infarct volume or NGF level. These results suggest that 14 days of treatment with H. erinaceum prior to MCA occlusion protected against focal cerebral ischemia, by increasing NGF levels. This implies that H. erinaceum and its components could be useful for preventing cerebral infarction.
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