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J.Health Sci., 55(5), 805-808, 2009
Effect of Momordica charantia on Adenosine Monophosphate-activated Protein Kinase in Genetically Type 2 Diabetic Mice Muscle
Toshihiro Miura,*, a Takanori Kawata,a
Satoshi Takagi,b Mai Nanpei,a
Haruka Nakao,a Eriko Ishihara,a
and Torao Ishidac
aDepartment of Clinical Nutrition,
bGraduate School of Health Science and
cHi-tech Research Center, Suzuka University of Medical Science, 1001-1 Kishioka, Suzuka, Mie 510-0293, Japan
The hypoglycemic activity of Momordica charantia L. (Cucurbitaceae) (MC) was investigated in KK-Ay mice, an animal model of type 2 diabetes. The water extract of the fruit of MC (100 mg/kg) reduced the blood glucose of KK-Ay mice 2 and 4 hr after oral administration (p<0.05). In addition, the muscle adenosine monophosphate-activated protein kinase (AMPK) was significantly activated in the orally MC-treated mice when compared to that of the controls (p<0.01). These results suggest that the antidiabetic effect of MC is derived, at least in part, from an activation of AMPK in the muscle.
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