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J.Health Sci., 55(2), 311-313, 2009
Nuclear Factor κB Inhibition by Dibenzoylmethane Derivatives
Nobuyasu Matsuura,*, a Rika Murakami,b
Tomoyuki Katayama,a Satoshi Hibino,c
Tominari Choshi,c and Masashi Yamadad
aDepartment of Life Science, Faculty of Science, Okayama University of Science, 1-1 Ridai-cho, Okayama 700-0005, Japan,
bResearch Planning Department Division of Research and Development, Meiji Dairies Corporation, 540 Naruda, Odawara, Kanagawa 250-0862, Japan,
cFaculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, 1 Sanzo, Gakuencho, Fukuyama, Hiroshima 729-0292, Japan and
dProduct Research, Licensing and AllianceManagement, Taiho Pharmaceutical Co. LTD, 1-2-4 Uchikanda, Chiyoda-ku, Tokyo, 101-0047, Japan
We established stable HeLa transformants with reporter genes containing nuclear factor (NF)-κB response elements to measure NF-κB inhibition. Tumor necrosis factor (TNF)-α treatment induced a 6-fold activation of NF-κB in HeLaNF-κB-3 cells. Three chloro-derivatives of fourteen dibenzoylmethane derivatives inhibited NF-κB activity.
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