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J.Health Sci., 54(5), 559-566, 2008
Oral Intake of Glucosylceramide Improves Relatively Higher Level of Transepidermal Water Loss in Mice and Healthy Human Subjects
Taro Uchiyama,*, a Yusuke Nakano,a
Osamu Ueda,a Hiroshi Mori,a
Masaya Nakashima,a Akira Noda,a
Chiaki Ishizaki,b and Masako Mizoguchic
aFunctional Food Development Group, Functional Food Research & Development Center, Shiseido Co., Ltd. Research Center (Kanazawa-Hakkei), 2-12-1 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-8643, Japan,
bShinjuku Minamiguchi Hifuka, 1-18-7 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan and
cSt. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa 216-8511, Japan
We examined the effect of oral intake of pure glucosylceramide derived from konjac extract on skin barrier function evaluated by transepidermal water loss (TEWL) in hairless mice with sodium dodecyl sulfate (SDS)-induced skin roughness. The difference of TEWL between SDS-treated site and untreated sites in the pure glucosylceramide-fed group was significantly lower than that in control group on day 14 of ingestion. We investigated interleukin-1α (IL-1α) production in the hairless mouse skin, and it was significantly lower in the glucosylceramide-fed group than that of control animals. This reduced IL-1α production should contribute to improvement of skin barrier function. To investigate the effect of oral intake of glucosylceramide in human, we conducted a randomized double-blind placebo-controlled study including 100 healthy subjects whose TEWL in cheek was relatively high. As a result, cheek TEWL was significantly lower in the test product group as compared with the control group in weeks 8 and 12 of ingestion (p=0.023 and p=0.002 respectively).
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