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J.Health Sci., 54(5), 544-550, 2008
Anxiolytic and Antiseizure Effects of Sida tiagii Bhandri
Ashok Kumar Datusalia,*, a Pankaj Kalra,a
Balasubramanian Narasimhan,a Sunil Sharma,a
and Ramesh Kumar Goyalb
aDepartment of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar-125001, India and
bL. M. College of Pharmacy, Ahemdabad-380009, India
The central nervous system (CNS) pharmacological effects of ethylacetate extract (EAS) of Sida tiagii Bhandri collected from northern province (Rajasthan) of India were assessed by elevated plus-maze, pentobarbitone induced sleeping time, spontaneous motor activity, pentylenetetrazole-induced seizure, forced swim test and rotarod tests. The results of the present study demonstrated the CNS depressant potential, i.e., anxiolytic, antiseizure, reduction in spontaneous locomotion and potentiation of pentobarbital-induced hypnosis of the plant under investigation.
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