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J.Health Sci., 54(2), 203-206, 2008
Effect of Tangzhiqing on Glucose and Lipid Metabolism in Genetically Type 2 Diabetes KK-Ay Mice
Wei Wang,a Toshihiro Miura,*, b
Hong Shi,a Dong-Ming Ma,a
Qi-Duo Zhao,a Wen-Ping Zhang,c
Eriko Ishihara,b Kanehara Masayuki,c
Bo Li Zhang,a Xiu Mei Gao,a
De Qin Zhang,a and Torao Ishidad
aTianjin University of Traditional Chinese Medicine, 312 Yuquan Road, Nankai District, Tianjin, China,
bDepartment of Clinical Nutrition, Suzuka University of Medical Science, 1001-1 Kishioka, Suzuka, Mie 510-0293, Japan,
cFaculty of Acupuncture and Moxibustion, Suzuka University of Medical Science, 1001-1 Kishioka, Suzuka, Mie 510-0293, Japan, and
dHi-tech Research Center, Suzuka University of Medical science, 1001-1 Kishioka, Suzuka, Mie 510-0293, Japan
The hypoglycemic and hypolipidemic effects of Tangzhiqing (abbreviated TZ) a mixture of Mulberry Leaf, Lotus Leaf, Danshen Root, and Hawthorn Leaf, were investigated in KK-Ay mice, an animal model of type 2 diabetes. TZ reduced blood glucose, total cholesterol, and triglyceride levels of KK-Ay mice at 4 weeks after oral administration. TZ also improved sucrose or maltose tolerance. Maltase activity in small intestine significantly decreased in the TZ-treated KK-Ay mice. These results support the hypothesis that TZ improves glucose metabolism by reducing α-glycosidase activity. Therefore TZ might have beneficial effects on hyperglycemia and hyperlipidemia in type 2 diabetes.
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