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J.Health Sci., 54(1), 17-22, 2008
Chlorination Byproducts of Epoxy Resin Hardener and Mutagenic Assay of Their Products
Satoshi Tomiyama,a Yasuo Takahashi,*, b
Kumiko Yaguchi,b and Sukeo Onoderaa
aFaculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda-shi, Chiba 278-8510, Japan and
bTokyo Metropolitan Research Laboratory of Public Health, 3-24-1 Hyakunincho, Shinjuku-ku, Tokyo 160-0073, Japan
The reaction of 4,4'-methylenedianiline (MDA) with chlorine in aqueous solution was investigated by gas chromatography/mass spectrometry (GC/MS) in order to determine its chemical changes in water. MDA was shown to react readily with chlorine under conditions likely to be found during water treatment disinfection. The reaction of MDA with chlorine in water was dependent on the solution pH and the molar ratios of chlorine to MDA. The disinfection products of p-benzoquinone, p-chloroaniline, 2,4-dichloroaniline, 2,4,6-trichloroaniline, and p-aminophenol were identified and them of p-aminobenzyl chloride, p-aminobenzaldehyde and p-methoxyaniline were estimated in the chlorination MDA solution. The mutagenic activity of the chlorination byproducts extracted from the chlorination MDA solution was evaluated using umu-test.
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