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J.Health Sci., 53(6), 745-749, 2007
ANDP-2, A Novel Acrinol Degradation Product by Light
Tomonori Iijima,a Teruo Tanaka,*, a
Toshimasa Yoshioka,a Yuki Ichioka,a
Masashi Hirano,a Masami Nishiyama,a
Yutaka Kido,a Toshiharu Tanaka,b
and Tetsumi Iriec
aDivision of Instrumental Analysis, Institute of Resource Development and Analysis, Kumamoto University, 5-1 Oehonmachi, Kumamoto 862-0973, Japan,
bAso Pharmaceutical Co., Ltd., 91-1 Tsukure, Kikuyomachi, Kikuchi-gun, Kumamoto 869-1101, Japan, and
cDepartment of Clinical Chemistry & Informatics, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan
To clarify the degradation pathway of acrinol by light, isolation and identification of acrinol degradation products (ANDP) were attempted. ANDP-2, one of the ANDPs, was isolated by extraction with methanol from cloths dampened with acrinol solution, and purified by column chromatography on Diaion HP-10, Sephadex LH-20 and G-25. The structural elucidation of ANDP-2 was examined by infrared, 1H-NMR, 13C-NMR and Fast atom bombardment mass (FAB-MS) spectra studies. From the spectroscopic data, the structure of ANDP-2 was determined to be 4-amino-6-ethoxyl-2,3-dicarboxyquinoline, that was found to be a novel degradation product of acrinol by light. The solution of ANDP-2 has fluorescence with a blue color, though that of acrinol has fluorescence with green. ANDP-2 did not show growth inhibition at a concentration of 100 μg/ml against Gram-positive, -negative bacteria, yeast and fungi.
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