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J.Health Sci., 53(5), 520-526, 2007
Comparison of the Effects of Pantoprazole and Its Enantiomers on Gastric Acid, Mucus, and Mucosa as Well as Endocrine Cells
Hong Cao,a Hui Meng,b
Li-Xin Sun,a Min-Wei Wang,a
Huai-De Su,c Mao-Sheng Cheng,d
Zhi-Qing Hu,e and Wei-Hua Zhao*, e
aDepartment of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning 110016, China,
bDepartment of Pathology, China Medical University, 92-Beier Road, Heping District, Shenyang, Liaoning 110001, China,
cState Food and Drug Administration, A 38, Beilishi Road, Xicheng District, Beijing 100810, China,
dDepartment of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning 110016, China, and
eDepartment of Microbiology and Immunology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan
Pantoprazole is an excellent proton pump inhibitor for the treatment of acid-related lesions. In this study we compared the pharmacodynamic effects of (±)-pantoprazole sodium [(±)-PAN·Na] and its enantiomers on gastric acid secretion and their possible side effects on gastric mucus, mucosa, and gastric endocrine cells. (±)-PAN·Na, (-)-PAN·Na, and (+)-PAN·Na dose-dependently inhibited the secretion of basal gastric acid and histamine-induced gastric acid, and (-)-PAN·Na showed the most potent effect, which was confirmed in an in vivo experiment in rabbits and in an in vitro experiment using the stomachs of juvenile rats. On the other hand, (-)-PAN·Na, (+)-PAN·Na, and (±)-PAN·Na did not influence significantly the free and barrier mucus content in rats with short-term administration for 3 days. No obvious differences were observed in serum gastrin levels, volume densities of parietal cells, G cells and D cells, mucosal thickness, or relative stomach weight and body weight among the rats administered (-)-PAN·Na, (+)-PAN·Na, or (±)-PAN·Na for 40 days. Direct administration of (-)-PAN·Na can inhibit gastric acid secretion more effectively with no increase in side effects.
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