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J.Health Sci., 53(2), 202-208, 2007
Preventive Effects of Saldi tierra Containing Various Trace Elements on Bone Loss in Rats with Diabetes or Adjuvant Arthritis
Masayoshi Yamaguchi,*, a Satoshi Uchiyama,a
and Shigeo Kounob
aLaboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan and
bResearch & Development, Tokai Ever Clean Ltd., 1099-1 Kawajiri, Yoshida-chou, Haibara-gun, Shizuoka 421-0302, Japan
The preventive effect of Saldi tierra containing various trace elements on bone loss which is induced in rats with diabetes or adjuvant arthritis were investigated. Rats received a single subcutaneous administration of streptozotocin (STZ) (6.0 mg/100 g body weight), and the animals were orally administered a solution of Saldi tierra (25 or 50 mg/100 g) once daily for 14 days. STZ-administered rats caused a significant increase in serum glucose, triglyceride, or calcium levels and a significant decrease in body weight or serum inorganic phosphorus levels. These alterations were significantly restored after the oral administration of Saldi tierra. The femoral-diaphyseal and -metaphyseal calcium contents were significantly decreased in STZ-diabetic rats. This decrease was significantly inhibited after the administration of Saldi tierra (25 or 50 mg/100 g). The decreases in diaphyseal and metaphyseal alkaline phosphatase activity and metaphyseal DNA content were significantly prevented after the administration of Saldi tierra (50 mg/100 g). Meanwhile, rats received an injection of 1% Mycobacterium butyricum suspension into the subplantar surface of the right hind paw, and the animals were orally administered Saldi tierra (50 mg/100 g) once daily for 18 days. Calcium content, alkaline phosphatase activity, and DNA content in the femoral-metaphyseal tissues were significantly decreased in rats with adjuvant arthritis. These decreases were significantly inhibited after the administration of Saldi tierra (50 mg/100 g). This study demonstrates that the intake of Saldi tierra has preventive effects against bone loss in rats with diabetes or adjuvant arthritis in vivo.
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