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J.Health Sci., 53(2), 185-189, 2007
Analysis of Genetic Determinants Involved in Multiresistance in Clinical Strains Isolated from Renal Transplantation Recipients in Guangzhou, China
Lei Shi,a Yali Kou,a
Lin Li,a and Shin-ichi Miyoshi*, b
aCollege of Food and Biological Engineering, South China University of Technology, 510640 Guangzhou, China and
bGraduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan
In the present study, we examined the antibiotic sensitivity of 19 bacterial strains [5 coagulase-negative Staphylococcus, 2 methicillin-resistant Staphylococcus aureus (S. aureus), 2 Enterococcus faecium (E. faecium), 5 Escherichia coli (E. coli), 3 Cedecea sp., 1 Klebsiella pneumoniae (K. pneumoniae), and 1 Burkholderia cepacia (B. cepacia)], which were isolated from renal transplantation patients using the Kirby-Bauer method. We also investigated the production of β-lactamase and extended-spectrum β-lactamase (ESBL), and the presence of the integrase gene (intI1) and resistance gene cassette. Among the 19 strains tested, all displayed severe multiresistance, and 12 strains produced β-lactamase, in which 6 strains were ESBL positive. Eleven strains were revealed to possess the class 1 integron; however, neither class 2 nor 3 was detected. Additionally, 3 drug resistance genes, aadA2, dfrA17, and aadA5, were found in some strains. The results indicate that the horizontal transfer of the β-lactamase gene and/or the class 1 integron may contribute significantly to the spread of multiresistant bacteria among renal transplantation patients.
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