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J.Health Sci., 53(1), 23-30, 2007
Relationship between tumorsize of malignant pleural mesothelioma and its response to chemotherapy
Hilmi Ozden,*, a Güntülü Ak,b
Selma Metintas,c Muzaffer Metintas,b
Bünyamin Sahin,d Sinan Erginel,b
and Kismet Civie
aDepartment of Anatomy,
bDepartment of Chest Disease,
cDepartment of Public Health, Eskisehir Osmangazi University Medical School, 26040, Eskisehir, Turkey,
dDepartment of Anatomy, Ondokuz Mayis University Medical School, 55010 Samsun, Turkey, and
eDepartment of Pathology, Dumlupinar University, Education and Training Haspital, 43405, Kutahya, Turkey
Purpose: Malignant pleural mesothelioma (MPM) is an extremely lethal neoplasm and continues to be an important health problem in communities facing occupational or environmental exposure to asbestos. One of the most significant problems in the treatment of MPM is the lack of a standardized criterion for the evaluation of response to chemotherapy. In this study, differences between the tumor volumes of International Mesothelioma Interest Group (IMIG) stages, chemotherapy response, and patient response times were investigated. Patients and methods: We used the initial tumor volume determinations from patients with MPM with the point-counting technique indicated in the Cavalieri principle of stereologic design. Results: We observed reduction in tumor volumes from tumor treatment until posttreatment. We found that those patients with the shortest period between initial diagnosis of a tumor volume of 200 mm3 or greater had increases in volume of greater than 50 mm3. Conclusion: There is still no standardized evaluation of MPM responses after chemotherapy to chemotherapy using classic criteria. However, our studies on tumor volume continuer.
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