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J.Health Sci., 53(1), 119-123, 2007
Two Sensitive Sick-building Syndrome Patients Possibly Responding to p-Dichlorobenzene and 2-Ethyl-1-Hexanol: Case Report
Fumio Kondo,*, a Yoshitomo Ikai,a
Tomomi Goto,a Yuko Ito,a
Hisao Oka,a Hiroyuki Nakazawa,b
Yasuhei Odajima,c Michihiro Kamijima,d
Eiji Shibata,e Shinpei Torii,f
and Yutaka Miyazakia
aDepartment of Toxicology, Aichi Prefectural Institute of Public Health, 7-6 Nagare, Tsuji-machi, Kita-ku, Nagoya 462-8576, Japan,
bDepartment of Analytical Chemistry, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan,
cDepartment of Pediatrics, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan,
dDepartment of Occupational and Environmental Health, Nagoya University, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan,
eDepartment of Health and Psychosocial Medicine, Aichi Medical University, Nagakute, Aichi 480-1195, Japan, and
fDepartment of Domestic Science, Aichigakusen University, Okazaki, Aichi 444-0902, Japan
Sick-building syndrome (SBS) symptoms associated with indoor air volatile organic compounds (VOCs) in new or newly remodeled houses have been increasingly highlighted, and are known as “sick house syndrome” in Japan. In the course of the investigation of SBS patients, we found two sensitive patients who complained of severe symptoms and had elevated serum levels of p-dichlorobenzene and 2-ethyl-1-hexanol. One patient was a housewife, who complained of various symptoms such as headache, itching eyes, nasal irritation, and night sweats and had a high serum level of p-dichlorobenzene (25.4 ng/ml). She showed some improvement of symptoms in association with the gradual decrease in p-dichlorobenzene concentrations in both her bedroom and her serum. The other patient was a female professor who had experienced mainly respiratory symptoms, such as nonproductive cough, throat irritation, etc. when she entered her office, classrooms, and a faculty meeting room in a university building. Her serum 2-ethyl-1-hexanol concentration was 4.6 ng/ml, which was more than 7.7-fold higher than that in four other patients with other onsets. The elevation of her serum 2-ethyl-1-hexanol level was assumed to be due to daily exposure in the university building.
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