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J.Health Sci., 52(5), 628-632, 2006
Preventive Effects of Acidic Xylooligosaccharide on Contact Hypersensitivity in Mice
Kyoji Yoshino,*, a
Naoki Higashi,b
and Kunimasa Kogac
aDepartment of Chemistry and Biochemistry, Numazu College of Technology, 3600 Ooka, Numazu, Shizuoka 410-8501, Japan,
bGraduate Schools of Human Health Science, Tokyo Metropolitan University, 3-6-33 Azuma-cho, Akishima, Tokyo 196-8540, Japan, and
cDepartment of Biological Science and Technology, Tokai University, 317 Nishino, Numazu, Shizuoka 410-0395, Japan
The preventive effects of acidic xylooligosaccharide against contact hypersensitivity were investigated in mice. Percutaneous administration of acidic xylooligosaccharide at a dose of 0.10 mg/ear exhibited suppressive activity against contact hypersensitivity in mice. Oral administration at a dose of 200 mg/kg body weight also showed the same effects. Xylan, xylobiose, and glucuronic acid, sugars related to acidic xylooligosaccharide, exhibited suppressive effects on contact hypersensitivity only following oral administration at a dose of 200 mg/kg body weight. These results suggest that daily intake of acidic xylooligosaccharide may be advantageous for the prevention of contact hypersensitivity.
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