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J.Health Sci., 52(4), 406-411, 2006
Effect of Repeated Small-Dose gamma-Ray Irradiation on Atopic Dermatitis in NC/Nga Mice
Su-Ping Fang, Yasuko Muto, Fumitoshi Tago, Noriko Simura, and Shuji Kojima*
Department of Radiation Biosciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science (RIKADAI), 2641 Yamazaki, Noda-shi, Chiba 278ﾐ8510, Japan
We previously showed that several small-dose 0.5 Gy whole-body gamma-ray irradiation inhibits tumor growth in mice via elevation of the interferon
(IFN)-gamma/interleukin 4 (IL-4) ratio concomitantly with a decrease in the percentage of B cells. Here, we examined whether repeated small-dose (0.5 Gy, 10 times) gamma-ray irradiation influences atopic dermatitis in an NC/Nga mouse model. It was found that repeated gamma-ray irradiation increased total IgE in comparison with the disease-control group. Levels of IL-4 and IL-5 were increased versus the disease-control group, while IFN-gamma was slightly decreased, resulting in a further decrease of the IFN-gamma/IL-4 ratio compared with the disease-control group. These results indicate that repeated small-dose gamma-ray irradiation may exacerbate atopic dermatitis. This may be because the irradiation induces not helper T lymphocyte 1 (Th1), but Th2 polarization in this atopic mouse model, i.e., the effects of small-dose irradiation may be different in conditions involving immune hypersensitivity and impaired immunity.
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