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J.Health Sci., 52(4), 383-389, 2006
DA-9601 Decreases Immediate-Type Allergic Reaction and Tumor Necrosis Factor-alpha Production
Hyo-Hyun Park,a Sug-Hyun Kim,a, b
Soyoung Lee,a Jin-Young Moon,b
Won-Hwan Park,b Cheorl-Ho Kim,c
Jae Myung Chung,d Tae-Young Oh,e
Chang-Duk Jun,f
and Sang-Hyun Kim*, a
aDepartment of Pharmacology, School of Medicine, Kyungpook National University, 2-101 Dong-in-dong, Jung-gu, Daegu 700-422, Korea,
bCardiovascular Medical Research Center and Dept. of AM-Pointology & Diagnostics, Dongguk University, 707 Suk-jang-dong, Kyung-ju, Kyungpook 780-714, Korea,
cDepartment of Biological Science, SungKyunKwan University, 300 Chon-chon-dong, Jang-an-gu, Suwon 440-746, Korea,
dDepartment of Emergency Medicine, Kyungpook National University Hospital, 2-101 Dong-in-dong, Jung-gu, Daegu 700-422, Korea,
eDong-A Pharmaceutical Research Institute, 47-5 Sang-gal-dong, Giheung-gu, Yongin 449-905, Korea, and
fDepartment of Life Science, Gwangju Institutive of Science and Technology, 1 Oryong-dong, Buk-gu, Gwangju 500-712, Korea
The immediate-type allergic reaction is involved in many allergic diseases such as asthma, allergic rhinitis, and sinusitis. The discovery of drugs for the treatment of immediate-type allergic disease is a very important subject in human health. The formulated ethanol extract of
Artemisia asiatica Nakai (DA-9601) has been reported to have anti-oxidative and anti-inflammatory activities. In this report, we investigated the effect of DA-9601 on the immediate-type allergic reaction and studied its possible mechanisms of action, focusing on the mast cell-mediated allergic reaction. DA-9601 inhibited compound 48/80-induced systemic anaphylactic reactions and serum histamine release in mice. DA-9601 decreased the IgE-mediated passive cutaneous anaphylaxis, the model of local allergic reaction in vivo. DA-9601 dose-dependently reduced histamine release from mast cells activated by compound 48/80 or IgE. Furthermore, DA-9601 decreased the gene expression and production of tumor necrosis factor (TNF)-alpha in phorbol 12-myristate 13-acetate plus A23187-stimulated mast cells. These findings provide evidence that DA-9601 could be a candidate as an anti-allergic agent.
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