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J.Health Sci., 52(3), 252-258, 2006
Anti-Stress Effect of BRAND'S Essence of Chicken (BEC) on Plasma Glucose Levels in Mice Loaded with Restraint Stress
Hiroshi Kurihara,a Xin-Sheng Yao,a Hajime Nagai,b Nobuo Tsuruoka,c Hiroshi Shibata,c Yoshinobu Kiso,c and Harukazu Fukami*, d
aInstitute of Traditional Chinese Medicine and Natural Products, Jinan University, 601, Huangpu Avenue West, Guangzhou, 510632, China, bBRAND'S Centre for Health and Nutritional Sciences, Cerebos Pacific Ltd., 18 Cross Street #12-01/08, China Square Central, Singapore 048423, Singapore, cInstitute for Health Care Science, Research Center, Suntory Ltd., 1-1-1, Wakayamadai, Shimamoto-cho, Mishima-gun, Osaka 618-8503, Japan, and dDepartment of Bioscience and Biotechnology, Faculty of Bioenviromental Science, Kyotogakuen University, 1-1, Nanjo, Sogabe, Kameoka city, Kyoto 621-8555, Japan
We investigated the effect of BRAND'S Essence of Chicken (BEC) on the basic metabolism of blood glucose in mice loaded with restraint stress. In the glucose intravenously treated mice, the stress prolonged the half-life period (T1/2) of elimination for blood glucose from 51.7 to 62.2 min. The elimination rate decreased to 82.5% per min in stressed mice compared with a starved control. The T1/2 of blood glucose was 55.2 min in the BEC treated group. BEC alleviated a stress-induced decrease in blood glucose. The improved glucose metabolism was well explained by the findings that insulin levels were elevated and glycogen synthesis in liver was remarkably activated by BEC. Our study demonstrates that BEC improves metabolic dysfunction of blood glucose by elevating insulin levels reduced by restraint stress.
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