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J.Health Sci., 52(1), 17-23, 2006
The Protective Effect of BRAND'S Essence of Chicken (BEC) on Energy Metabolic Disorder in Mice Loaded with Restraint Stress
Hiroshi Kurihara,a Xin-Sheng Yao,a Hajime Nagai,b Nobuo Tsuruoka,c Hiroshi Shibata,c Yoshinobu Kiso,c and Harukazu Fukami*, c
aInstitute of Traditional Chinese Medicine and Natural Products, Jinan University, 601, Huangpu Avenue West, Guangzhou, 510632, China, bBRAND'S Center for Health and Nutritional Sciences, Cerebos Pacific Ltd., 18 Cross Street #12-01/08, China Square Central, Singapore 048423, Singapore, and cInstitute for Health Care Science, Technological Development Center, Suntory Ltd., 5-2-5, Yamazaki, Shimamoto-cho, Mishima-gun, Osaka 618-0001, Japan
We investigated the effects of BRAND'S Essence of Chicken (BEC) on the basic metabolism of plasma lipids in mice loaded with restraint stress. When a lipid emulsion was intravenously injected into mice, 20 hr restraint stress prolonged the elimination of plasma triglyceride (TG). The results indicated that lipid metabolism was definitely disrupted by stress, and that the use of TG as an energy source decreased. The plasma TG level was 320 ± 27 mg/dl 35 min after Intralipid® administration in restrained mice, while it was 253 ± 23 mg/dl in the restrained mice that were given 5 ml/kg of BEC. The improved plasma lipid metabolism was well explained by the finding that lipoprotein lipase in omental adipose tissue was remarkably improved by BEC. Our study shows that BEC improves metabolic dysfunction possibly by utilizing plasma lipids as energy sources and elevating lipoprotein lipase activity reduced by stress. The anti-stress effect of BEC may partly be related to improved plasma lipid metabolism for energy utilization.
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