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J.Health Sci., 51(6), 738-743, 2005
Relationship between Serum beta-Cryptoxanthin and Circulating Bone Metabolic Markers in Healthy Individuals with the Intake of Juice (Citrus unshiu) Containing beta-Cryptoxanthin
Masayoshi Yamaguchi,*, a Aki Igarashi,a Seiichi Morita,b Takashi Sumida,b and Kuniaki Sugawarab
aLaboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan and bResearch & Development, Ehime Beverage, Inc., 478 Anjyoji-machi, Matsuyama, Ehime 791-8603, Japan
The relationship between the serum beta-cryptoxanthin concentration and circulating biochemical markers of bone metabolism in healthy individuals with the intake of juice prepared from Satsuma mandarin (Citrus unshiu MARC.) containing beta-cryptoxanthin was investigated. Twenty volunteers (10 men and ten women) were divided into two groups of 10 volunteers (5 men and 5 women) each, and each group was sequentially given juice (192 ml) containing two different amounts of beta-cryptoxanthin once a day for 56 days as follows: either regular juice with naturally occurring beta-cryptoxanthin 802 mu g/100 ml or reinforced juice containing beta-cryptoxanthin 1500 mu g/100 ml. gamma-Carboxylated osteocalcin, which is a marker of bone formation, and bone tartrate-resistant acid phosphatase (TRAP), which is a marker of bone resorption, were assayed. The serum beta-cryptoxanthin concentration was significantly increased with the intake of regular juice for 56 days. This increase was significantly enhanced by the intake of beta-cryptoxanthin-reinforced juice. The intake of regular juice or of beta-cryptoxanthin-reinforced juice for 56 days caused a significant increase in serum gamma-carboxylated osteocalcin and a significant decrease in serum bone TRAP activity. A positive relationship between serum beta-cryptoxanthin and circulating gamma-carboxylated osteocalcin concentrations was found using the value obtained from all groups for before intake and with the intake of regular juice and beta-cryptoxanthin-reinforced juice. A negative relationship between serum beta-cryptoxanthin concentration and circulating TRAP activity was observed. This study shows that a relationship between serum beta-cryptoxanthin and circulating bone metabolic markers is found in healthy individuals with the intake of juice containing beta-cryptoxanthin.
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