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J.Health Sci., 51(6), 720-727, 2005
Proteoglycan Synthesis is Not Influenced by Zinc in Proliferating Bovine Aortic Endothelial Cells in Culture
Yasuyuki Fujiwara,a Anna H. Plaas,b and Toshiyuki Kaji*, a, c
aDepartment of Environmental Health, Faculty of Pharmaceutical Sciences, Ho-3 Kanagawa-machi, Kanazawa 920-1181, Japan, bDepartment of Internal Medicine, College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., Tampa, FL 33612-4799, U.S.A., and cOrganization for Frontier Research in Preventive Pharmaceutical Sciences, Hokuriku University, Ho-3 Kanagawa-machi, Kanazawa 920-1181, Japan
Zinc promotes the proliferation of bovine aortic endothelial cells depending on endogenous fibroblast growth factor-2 whose activity is modulated by proteoglycans. In this study, we investigated the effects of zinc on the synthesis of proteoglycans in proliferating cells. It was demonstrated that zinc neither influenced the core protein synthesis nor the glycosaminoglycan chain formation during the synthesis of proteoglycan molecules, suggesting that zinc stimulation of endothelial cell proliferation is independent of proteoglycan synthesis.
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