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J.Health Sci., 51(5), 538-548, 2005
Simultaneous Analysis of Endocrine Disruptors, 4-Alkylphenol and Bisphenol A, Contained in Synthetic Resin Products Used for Drug Containers and Household Utensils
Katsumi Sakurai,*, a Naeko Sugaya,a Tomoo Nakagawa,a Taketo Uchiyama,b Yasuo Fujimoto,c and Kunio Takahashid
aYokohama City Institute of Health, 1-2-17 Takigashira, Isogo-ku, Yokohama 235-0012, Japan, bCollege of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba 274-8555, Japan, cCollege of Humanities and Sciences, Nihon University, 3-25 Sakurajyosui, Setagaya-ku, Tokyo 156-8550, Japan, and dMeiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan
The chemical structures of individual isomers present in a mixture of 4-nonylphenol have recently been clarified, and differences in estrogen activity due to differences in the structure have been reported. Considering the importance of investigations of the chemical structure of 4-nonylphenol contained in commonly used synthetic resin products, we investigated an analytical method of individual isomers of 4-nonylphenol using positive chemical ionization-gas chromatography/mass spectrometry (PCI-GC/MS). Furthermore, we established a highly sensitive simultaneous analysis method using PCI-GC/MS [selected ion monitoring (SIM)], in which 4-alkylphenol and bisphenol A were extracted using a simple dissolution method without pretreatment such as solid-phase extraction and derivatized by trimethylsilylation.
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