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J.Health Sci., 51(4), 488-491, 2005
Prenatal Exposure to a Low Dose of 4-Hydroxy-2', 3, 3', 4', 5'-Pentachlorobiphenyl Increases Emotional Behaviors in Mice
Fumio Soeda, Taku Kaitsuka, Tetsuya Shirasaki, and Kazuo Takahama*
Department of Environmental and Molecular Health Sciences, Graduate School of Pharmaceutical Sciences Kumamoto University, 5-1 Oe-Honmachi, Kumamoto 862-0973, Japan
Hydroxylated polychlorinated biphenyl (OH-PCB) is a major metabolite of PCB, which is an endocrine disruptor. In this study, we investigated the neurobehavioral effects of prenatal exposure to a very low dose of OH-PCB (4-hydroxy-2', 3, 3', 4', 5'-pentachlorobiphenyl, 4-OH-pentaCB) in mice. 4-OH-pentaCB, dissolved in corn oil, was orally given at 0.1 mu g/30 mu l/animal/day to pregnant mice from gestation days 11 to 17. In the open field test, the number of ambulation and rearing drastically increased among 4-OH-pentaCB exposed mice compared with the control. However, 4-OH-pentaCB exposure had no effect on passive avoidance. These results suggest that an extremely low dose of 4-OH-pentaCB may selectively disrupt neurobehavioral functions involved in ambulation and rearing in mice.
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