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J.Health Sci., 51(3), 394-397, 2005
Proportion of Murine Cytotoxic T Cells is Increased by High Molecular-Weight Fucoidan Extracted from Okinawa mozuku (Cladosiphon okamuranus)
Jun Shimizu,*, a Urara Wada-Funada,a Hiroshi Mano,a Yoshiharu Matahira,b Mitsuaki Kawaguchi,b and Masahiro Wadaa
aDepartment of Clinical Dietetics & Human Nutrition, Faculty of Pharmaceutical Science, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan and bResearch & Developing Division, Yaizu Suisankagaku Industry Co., Ltd., 5-8-13 Ogawashinmachi, Yaizu, Shizuoka 425-8570, Japan
Male BALB/c mice were administered three fucoidans with different molecular weights prepared from Okinawa mozuku (Cladosiphon okamuranus). The proportion of CD8+ cells in the spleens of mice fed with high molecular-weight fucoidan significantly increased compared with those in mice fed a control diet. In addition, the CD4+/CD8+ ratio tended to decrease and the proportion of CD11b+ cells to increase. These results suggest that high molecular-weight fucoidan promotes an increase in the proportion of murine cytotoxic T cells.
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