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J.Health Sci., 51(2), 237-241, 2005
Random Brownian Motion Regulates the Quantity of Human
Immunodeficiency Virus Type-1 (HIV-1) Attachment and
Infection to Target Cell
Akira Tempaku*
School of Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Shimoaizuki, Matsuoka-cho, Yoshida-gun, Fukui
910-1193, Japan
The efficiency of human immunodeficiency virus
type-1 (HIV-1) infection in GHOST/CXCR4 cell was controlled by the frequency of virus access, which was
limited by random Brownian motion. Prolonged exposure of cell to virus increased the number of
infection. Virus migrated to cell, continuously, during
exposure period. Virus adsorption amount increased
kinetically. It was confirmed by measurement of
accumulated provirus DNA sum that the amount of virus
entry depended on exposure time. Increment of virus
adsorption amount and the number of infection followed to the theoretical manner that virus adsorption
dynamics was regulated by random Brownian motion.
This observation says that infectivity of lentivirus
vector (HIV-1 based) increases by exposure time
dependent way. This phenomenon is applicable to
enhancing the efficiency of gene transduction by lentivirus
vector.
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