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J.Health Sci., 51(2), 202-206, 2005
Influences of Polyaromatic Hydrocarbons and Heavy
Metals on a Thyroid Carcinoma Cell Line
Jun Kobayashi,*, a, b Ryoichi
Kizu,c and Hideo Sugiyamab
aLaboratory Science, School of Health Science, Faculty of
Medicine, Kanazawa University, 5-11-80 Kodatsuno, Kanazawa 920-0942, Japan,
bDepartment of Environmental Health, National Institute of Public Health, 2-3-6 Minami,
Wako, Saitama 351-0197, Japan, and cGraduate School of
Natural Science & Technology, Kanazawa University,
Kakuma-machi, Kanazawa 920-1192, Japan
We investigated the influences (cell toxicity,
endocrine disrupting action, etc.) of polyaromatic
hydrocarbons (PAHs) and heavy metals on the human
thyroid gland by using a cultured thyroid cancer cell
(8505C). Among the six PAHs tested (anthracene,
benzo[a]anthracene, benzo[a]pyrene,
benzo[k]fluoranthene, chrysene and pyrene), anthracene did
not show any effect, but cell proliferation was enhanced
by benzo[a]anthracene, benzo[a]pyrene and
benzo[k]fluoranthene. Benzo[a]pyrene had an especially
marked effect. On the other hand, cell toxicity was
exhibited in four (cadmium, copper, nickel and zinc)
of the twelve metals tested (aluminum, cadmium,
calcium, copper, lead, magnesium, manganese, nickel, tin,
zinc, selenate and selenite), and in particular, the
influence of cadmium was remarkable. It was found that
the toxicity of cadmium was decreased by the addition
of high concentrations of either calcium or selenite.
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