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J.Health Sci., 51(2), 191-196, 2005
Prolonged Intake of Dietary Fermented
Isoflavone-Rich Soybean Reinforced with Zinc Affects
Circulating Bone Biochemical Markers in Aged Individuals
Masayoshi Yamaguchi,*, a Aki
Igarashi,a Masakazu
Sakai,b Hideyuki
Degawa,c and Yoichi Ozawac
aLaboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52-1 Yada,
Shizuoka 422-8526, Japan, bDivision of Internal Medicine, Nishi-Kumamoto Hospital, 1012 Koga, Tomiai, Kumamoto 861-4157, Japan,
and cFood Science Laboratory, Taishi Foods Inc., 25-1 Shimomaegawara Osaka, Towada, Aomori 034-0041, Japan
Changes in circulating biochemical markers of bone metabolism in aged individuals with the intake of
fermented soybean (natto), which was made from isoflavone-rich soybean, supplemented with zinc were investigated.
Sixty-three volunteers (31 men and 32 women) were divided into four groups of 15 or 16 male volunteers and 16 or
16 female volunteers, and each group was sequentially given
natto (40-g pack) containing two different levels of
zinc once a day for 4 or 8 weeks as follows: either regular
natto with naturally occuring isoflavone 35.0 mg, zinc
0.8 mg and calcium 51.4 mg or supplemented
natto containing isoflavone 35.0 mg, zinc 3.6 mg, and calcium 60.0 mg.
As serum bone markers, bone-specific alkaline phosphatase,
gamma-carboxylated osteocalcin, bone tartrate-resistant acid
phosphatase (TRAP), and N-telopeptide of type I collagen were assayed. The intake of regular
natto for 4 or 8 weeks in men or women persons caused a significant increase in
gamma-carboxylated osteocalcin, a marker of bone formation,
and a significant decrease in serum bone N-telopeptide of type I collagen, a marker of bone resorption, as compared
with the value before intake. Moreover, the intake of zinc-supplemented
natto for 8 weeks in men or women caused a significant increase in serum bone-specific alkaline phosphatase activity and
gamma-carboxylated osteocalcin concentration and a significant decrease in serum bone TRAP activity and
N-telopeptide of type I collagen, as compared
with the values with the intake of regular
natto. This study suggests that the intake of regular
natto with isoflavone-rich soybean has a stimulatory effect on bone formation and an inhibitory effect on bone resorption in aged
individuals, and that the effect is enhanced by supplementation with zinc.
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