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J.Health Sci., 51(2), 161-171, 2005
Tea Catechins with a Galloyl Moiety Reduce Body
Weight and Fat
Osami Kajimoto,*, a Yoshitaka
Kajimoto,b Mitsuharu
Yabune,b Tadashi
Nakamura,c Kazuaki Kotani,c,
d Yuko Suzuki,e Ayumu
Nozawa,e Kozo
Nagata,e Tomonori
Unno,e Yuko Mitane Sagesaka,e Takami
Kakuda,e and Toshikazu
Yoshikawaf
aHealth Management Center, Osaka University of Foreign Studies, 8-1-1 Higashi Awaumatani, Minou-shi, Osaka 562-8558, Japan,
bDepartment of Clinical Trial and Research, Soiken Inc., 1-4-2 Shinshisato Higashimachi, Toyonaka-shi, Osaka 560-0082, Japan,
cGraduate School of Medical Research Molecular Control Internal Medicine, Osaka University, 2-2 Yamadaoka, Suita-shi, Osaka
565-0871, Japan, dOsaka Kenkou Club, Sekiyama Clinic, 4-10-1 Esaka-cho, Suita-shi, Osaka 564-0063, Japan,
eCentral Research Institute, ITOEN, Ltd., 21 Meoto, Aira-cho, Haruhara-gun, Shizuoka 421-0516, Japan, and
fFirst Department of Internal Medicine,
Kyoto Medical School, 465 Kajii-cho, Hirokoji-noboru, Kawaharamachi-dori, Kamikyo-ku, Kyoto 602-8566, Japan
We investigated the effect of consumption of a catechin-containing drink on body fat level and its safety in
healthy adults. The beverage (250 ml/bottle) contained 215.3 mg of tea catechins mostly possessing a galloyl
moiety, which included (-)-epigallocatechin gallate 74.6 mg, (-)-epicatechin gallate 34.1 mg, (-)-gallocatechin gallate
77.8 mg, (-)-catechin gallate 24.5 mg. We conducted a double-blind study with three parallel groups. Healthy
subjects (98 men and 97 women) aged from 20 to 65 years old with 22.5 < body mass index (BMI)
 30 kg/m2 were assigned to consume 3 bottles of placebo drink (control group), 2 bottles of catechin-containing drink and 1 bottle of
placebo drink (low-dose group), or 3 bottles of catechin-containing drink (high-dose group), per day at mealtimes
for 12 week (daily consumption of catechins was 41.1, 444.3 or 665.9 mg respectively). Compared to the value at
0 week, consumption of two or three bottles of catechin-containing drink results in significant decrease in body
weight and BMI at 8 and 12 or 4, 8 and 12 week, respectively. Body weight and BMI was significantly decreased in
both catechin groups compared with the control group from 4 to 12 week. The measurements of abdominal fat areas
indicated significant reduction of total fat area and visceral fat area in both catechin groups compared with the
control group at 12 week. Thus our present observations suggest that consumption of a catechin-containing drink
may be useful for the prevention of obesity-related disorders.
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