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J.Health Sci., 51(2), 147-154, 2005
Endogenous Level and in Vitro Production of GHB
in Blood from Healthy Humans, and the Interpretation of GHB Levels Detected in
Antemortem Blood Samples
Noriaki Shima,* Akihiro Miki, Tooru Kamata, Munehiro Katagi, and Hitoshi Tsuchihashi
Forensic Science Laboratory, Osaka Prefectural Police Headquarters, 1-3-18 Hommachi, Chuo-ward, Osaka 541-0053, Japan
The endogenous level of gamma-hydroxybutyric acid (GHB) and the
in vitro production of GHB in blood from healthy humans have been investigated. The endogenous GHB concentrations in aseptically collected whole blood
samples ranged from 5 to 10 ng/ml, which were far below the previously-reported "endogenous" levels . Also, the
levels of in vitro GHB production during storage for 16 months at 4°C were lower than
0.4 mu g/ml, which were much lower than those in postmortem samples previously reported. Based on the results of this investigation, the authors
concluded that an interpretative cutoff of
1.0 mu g/ml would be appropriate for differentiating exogenous from
endogenous GHB, if only limited to in-life blood specimens that were collected aseptically, stored at 4°C or lower,
examined within two weeks, and excludes the possibility of GHB aciduria.
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