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J.Health Sci., 51(2), 130-137, 2005
Detection of Bis(diphenylarsine)oxide,
Diphenylarsinic Acid and Phenylarsonic Acid, Compounds Probably Derived from Chemical Warfare Agents, in Drinking Well Water
Mutsuo Ishizaki,*, a Tomoko
Yanaoka,a Miki
Nakamura,a Tadao
Hakuta,a Seiichi
Ueno,a Michihiko
Komuro,a Miyako
Shibata,a Tatsumi
Kitamura,a Akira
Honda,a Mikio
Doy,a Kazuhiro
Ishii,b Akira
Tamaoka,b Nobuhiro
Shimojo,b Tsuyoshi
Ogata,c Eiko
Nagasawa,d and Shigeyuki Hanaokad
aIbaraki Prefectural Institute of Public Health, 993-2 Kasahara-cho, Mito-shi, Ibaraki 310-0852, Japan,
bUniversity of Tsukuba, 1-1 Tennodai, Tsukuba-shi, Ibaraki 305-8575, Japan,
cItako Health Center of Ibaraki prefecture, 1446-1 Oosu, Itako-shi, Ibaraki
311-2422, Japan, and dChemicals Evaluation and Research Institute, 1600 Shimo-Takano, Sugito-machi, Kitakatsushika-gun,
Saitama 345-0043, Japan
The inhabitants living in a specific region of Kizaki area in Kamisu-town, Ibaraki Prefecture exhibited
uncommon clinical central nervous system symptoms. A graphite furnace atomic absorption spectrophotometer
detected markedly elevated concentration of arsenic (4.5 ppm) in their drinking well water. Further investigation
using HPLC, GC/MS and HPLC/ICP/MS demonstrated that the structures of the arsenic were
bis(diphenylarsine)oxide (BDPAO), diphenylarsinic acid (DPAA) and phenylarsonic acid (PAA), compounds
that can be derived from the chemical warfare agents, diphenylchloroarsine (DA) and diphenylcyanoarsine
(DC). The predominant form of the arsenic compound in the well water was DPAA (maximum 15 ppm), so that
it was calculated that the inhabitants ingested 11-30 mg of DPAA daily. This is the first report of inhabitants that
were injured by drinking well water contaminated with organic arsenic compounds that were likely derived from
chemical weapons.
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