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J.Health Sci., 50(6), 674-678, 2004
Plasma Insulin Concentration was Increased by Long-Term
Ingestion of Guava Juice in Spontaneous
Non-Insulin-Dependent Diabetes
Mellitus (NIDDM) Rats
Masanori Sunagawa,*, a Seiji
Shimada,a
Zhe Zhang,a Akira
Oonishi,a, b
Mariko Nakamura,a
and Tadayoshi Kosugia
a1st Department of Physiology, Unit of Physiological Science,
School of Medicine, University of the Ryukyus, 207 Uehara,
Nishihara, Okinawa 903-0215, Japan and
bResearch Laboratory Serotec Co., Ltd., 132-1 Higashinopporo, Ebetsu,
Hokkaido 069-0822, Japan
To investigate whether long-term ingestion of
guava juice has anti-diabetes and/or anti-obese actions,
we employed spontaneous non-insulin-dependent
diabetes mellitus Otsuka Long-Evans Tokushima Fatty
(OLETF) rats and its control strain Long-Evans Tokushima Otsuka (LETO) rats. Thirty rats of each
strain were divided into three groups consisting of
glucose, vitamin E, and guava juice ingestion groups.
Ingestion of these test solutions was continued from 9 to
32 weeks old. Serum lipid parameters including total
cholesterol, triglyceride, free fatty acid, and
high-density lipoprotein (HDL)-cholesterol were measured.
Oral glucose tolerance test (OGTT) was performed at
32 weeks old rats and at 42 weeks old rats (10 weeks
after discontinue of ingestion of guava juice), and then
blood glucose levels and plasma insulin concentrations
were measured. There were no significant differences
in body weight, the amount of food intake and the
volume of drink among the groups in OLETF rats.
Although the blood glucose level in the guava juice group
was not changed as compared with the glucose group,
the amount of initial insulin secretion was significantly
increased in OLETF rats and was restored by
discontinue of ingestion of guava juice. Therefore, the
long-term ingestion of guava juice may increase plasma
insulin concentration in OLETF rats.
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