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J.Health Sci., 50(6), 619-624, 2004
Prolonged Intake of Juice (Citrus Unshiu)
Reinforced with beta-Crypthoxanthin Has an
Effect on Circulating Bone Biochemical
Markers in Normal Individuals
Masayoshi Yamaguchi,*, a Aki
Igarashi,a Satoshi
Uchiyama,a Seiichi
Morita,b
Kuniaki Sugawara,b and Takashi
Sumidab
aLaboratory of Endocrinology and Molecular Metabolism, Graduate School of Nutritional Sciences, University of Shizuoka, 52-1 Yada,
Shizuoka 422-8526, Japan and bResearch & Development, Ehime Beverage, Inc., 478 Anjyoji-machi, Matsuyama 791-8603, Japan
A change in circulating biochemical markers of bone metabolism in normal individuals with the intake of juice
prepared from Satsuma mandarin (Citrus
unshiu MARC.) containing beta-crypthoxanthin was investigated.
Twenty-one volunteers (ten males and eleven females) were divided into two groups of ten volunteers (five males and five
females) and eleven volunteers (five males and six females), and each group was given sequentially juice (192 ml)
containing two different contents of beta-crypthoxanthin once a day for 28 or 56 days as follows: either regular juice
with naturally occurring 802 mu g beta-cryptoxanthin/100 ml or a reinforced juice containing
1500 mu g beta-cryptoxanthin/100 ml. As serum bone markers, bone-specific alkaline phosphatase,
gamma-carboxylated osteocalcin, bone
tartrate-resistant acid phosphatase (TRAP), and N-telopeptide of type I collagen were assayed. The intake of regular juice for 28
or 56 days caused a significant increase in
gamma-carboxylated osteocalcin, a marker of bone formation, and the intake for
56 days produced a significant decrease in serum bone TRAP activity. Moreover, intake of the
beta-cryptoxanthin reinforced juice for 28 or 56 days caused a significant increase in serum
beta-carboxylated osteocalcin concentration and a corresponding decrease in serum bone TRAP activity and N-telopeptide of type I collagen, a marker of bone
resorption. This study suggests that the intake of
beta-cryptoxanthin reinforced juice has a stimulatory effect on bone
formation and an inhibitory effect on bone resorption in normal individuals.
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