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J.Health Sci., 50(5), 497-502, 2004
Transfer of Polycyclic Aromatic Hydrocarbons to
Fetuses and Breast Milk of Rats Exposed to Diesel Exhaust
Yoshiko Tozuka,a Nobue
Watanabe,b Masanobu
Osawa,b Akira
Toriba,a Ryoichi
Kizu,a and Kazuichi Hayakawa*, a
aDivision of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi,
Kanazawa, Ishikawa 920-1192, Japan and
bDepartment of Environmental Health, Tokyo Metropolitan Public Health Research
Institute, 3-24-1, Hyakunin-chyo, Shinjyuku-ku, Tokyo 169-0073, Japan
Polycyclic aromatic hydrocarbons (PAHs) were analyzed in maternal blood and fetuses from Fischer 344 rats
exposed to diesel exhaust (DE) during pregnancy, and in breast milk from rats exposed to DE during pregnancy and
lactation using high performance liquid chromatography with fluorescence detection. Concentrations of
phenanthrene (Phe), anthracene (Ant) and
benz[a]anthracene (BaA) were significantly higher in maternal blood of the DE
group than those of the control group. Concentration of Phe in fetuses of the DE group was significantly higher than
those of the control group. Concentrations of fluorene, Ant, fluoranthene (Flu), pyrene (Pyr), BaA and chrysene
(Chr) tended to be higher in fetuses of the DE group. The levels of Ant, Flu, Pyr and Chr in breast milk from the DE
group were significantly higher than those of the control group. These results indicate that PAHs taken into mother
rat by the inhalation of DE are transferred into fetuses
via placenta and into breast milk. This is the first report to
clarify the transportation of inhaled PAHs into fetuses and breast milk from mother rats.
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