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J.Health Sci., 50(5), 474-482, 2004
Curcumin Anticipates the Suppressed Body Weight Gain with 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in Mice
Takumi Ishida, Junko Taketoh, Emi Nakatsune, Shoko Kan-o, Eri Naito, Shuso Takeda,
Junpei Mutoh, Yuji Ishii, and Hideyuki Yamada*
Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
The protective effect of curcumin, a potent inducer of heat shock protein (Hsp) 70, against the acute toxicity
produced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was studied
in vivo in C57BL/6J mice. Curcumin reduced the loss of body weight gain produced by TCDD regardless of having no effect on hepatomegaly and
thymic atrophy. Hsp70.1 mRNA levels in liver and intestine were unaffected or tended to be reduced by TCDD
and/or curcumin treatment. Curcumin also had no effect on the induction of hepatic ethoxyresorufin
O-deethylase activity by TCDD. These data suggest that curcumin exhibits a protective effect against some forms of dioxin
toxicity by a mechanism(s) distinct from the increase in hepatic and intestinal Hsp70 and inhibition of
arylhydrocarbon receptor activation.
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