| |
Software Requirements
Microsoft Internet Explorer 5.01 or higher and Netscape Navigator 4.75 or higher are recommended. |
|
 |
J.Health Sci., 50(5), 443-455, 2004
-Review-
Strategy in a Living Body to Protect against Oxidative Stress-Induced Damage
Kiyomi Kikugawa*
School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
Oxidative stress derived from reactive oxygen species and/or heavy metal ions is believed to cause random
damage to components in a living body, as well as aging and/or various disorders. A variety of systems that protect
the living body from oxidative stress-induced damage are known; the present author elucidated three new defense
systems against oxidative stress. Firstly, although it has been thought that lipid peroxidation in the living body
promotes oxidative stress and increases the degree of oxidative damage, it was found that lipid peroxidation
attenuated the DNA damage induced by such stress. This was determined by careful estimation of in situ lipid peroxidation.
Secondly, red blood cells suffered from oxidative stress during their circulation, and membrane band 3 became
aggregated and clustered so that anti-band 3 IgG and macrophages attached to it through sialylated
poly-N-acctyllactosaminyl (PL) sugar chains. The PL sugar chain attachment to macrophages was stimulated by oxidative
stress in the macrophages. Thirdly, the presence of oxidized protein hydrolase (OPH) that preferentially hydrolyzed
proteins damaged by oxidative stress was found, and this enzyme may constitute a secondary defense system of the
cells against such stress.
|
|
