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J.Health Sci., 50(4), 413-416, 2004
Classical Conditioning of Metallothionein Synthesis in Mice
Masuo Kondoh,a Daisuke Kodama,b Yoshiteru Watanabe,a and Masao Sato*, b
aDepartment of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University, 3-3165, Higashi-tamagawagakuen Machida, Tokyo 194-8543, Japan and bFaculty of Pharmaceutical Sciences, Tokushima Bunri University, 180 Yamashiro-cho, Tokushima 770-8514, Japan
To clarify the role of metallothionein (MT), an anti-stress protein, induced by psychological stress, we carried out an experiment to determine whether hepatic MT synthesis induced by restraint stress can be classically conditioned by an olfactory odor cue of camphor. Mice were conditioned by exposure to the odor of camphor 1 hr before restraint stress and partly during restraint stress. Although exposure to the odor of camphor did not elevate hepatic MT levels in itself, the odor stimuli significantly elevated hepatic MT levels in mice conditioned for 3 days. The results indicate that MT synthesis is induced by an association of the central nervous system with psychological stress.
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