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J.Health Sci., 50(3), 315-318, 2004
Dietary Bisphenol A Suppresses the Growth of Newborn Pups by Insufficient
Supply of Maternal Milk in Mice
Chiho Matsumoto, Chisato Miyaura,* and Akira Ito
Department of Biochemistry, School of Pharmacy, Tokyo
University of Pharmacy and Life Science, 1432-1, Horinouchi,
Hachioji Tokyo 192-0392, Japan
Bisphenol A (BPA), a monomer used for the
production of polycarbonate, is known to have estrogen
activity. In this study, pregnant mice were fed chow
diet containing 1% BPA, and we examined the
influence of dietary BPA on delivery and growth of
newborn pups in mice. When pregnant mice were fed BPA
diet, the mice normally delivered pups on day 21 of
gestation. The number of offspring pups in maternal
mice fed BPA diet was same to those fed normal diet.
Therefore, the growth of fetuses and the process of
delivery were not influenced by dietary BPA. However,
the growth of newborn pups was markedly suppressed
when maternal mice were fed BPA diet. The growth of
neonatal mice depends on breast milk, and stomach was filled with milk in pups. In newborn pups from
maternal mice supplemented with BPA diet, the weight
of stomach was lower than that from maternal mice
with normal diet. Since the serum level of prolactin
was limited in maternal mice supplemented with BPA
diet, the suppressed growth of newborn pups by dietary BPA may be due to the insufficient supply of
breast milk. These results suggest that the influence of
BPA on the growth of newborn pups is related to
hormonal condition in maternal mice.
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