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J.Health Sci., 50(3), 264-270, 2004
Predictable Increase of Central Nervous System Stimulation by
a Pyrolysis Product in Smoking Dimethylamphetamine
Motoyasu Sato,*, a Kenjiro
Ito,a and Hisamitsu
Nagaseb
aScientific Investigation Research Laboratory, Aichi Pref.
Police H.Q., 2-1-1 Sannomaru, Naka-ku, Nagoya 460-8502,
Japan and bGifu Pharmaceutical University, 5-6-1
Mitahora-higashi, Gifu 502-8585, Japan
We carried out a dimethylamphetamine (DMA) smoking experiment that is closer to some real cases.
In this study, we heated DMA hydrochloride (DMA-HCl) in the range of about 250°C to 350°C, in which
demethylation reaction occurred mainly, with a smoke collection apparatus and gas lighter, and
trapped the generating vapor with an adsorption
cartridge. The eluate desorbed from the cartridge and
residual materials inside the smoke collection
apparatus were analyzed by gas chromatography-mass
spectrometry and liquid chromatography-electrospray ionization-mass spectrometry.
Methamphetamine (MA) and amphetamine (AM) were
produced via demethylation from the dimethylamino group of DMA. Allylbenzene (AB),
benzaldehyde (BA), cis-beta-methylstyrene (cMS),
benzyl chloride (BC) and trans-beta-methylstyrene
(tMS) in addition to MA and AM, were also formed
as pyrolysis products. The molar percentages of a
pyrolyzate MA and AM to the starting DMA were 21.4 and 1.8%, respectively, and the total molar
percentage of AB, BA, cMS, BC and tMS was 2.9%. Taking into account the central nervous system
stimulation by DMA and MA in humans, the total stimulant effects of the drugs that are ingested in a
body can be calculatedly increased more than
fourfold by smoking DMA. The present data show that
a DMA smoking abuser may be able to get a more powerful stimulant effect by smoking than by
injecting.
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