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J.Health Sci., 50(2), 181-184, 2004
Promoter and Mutagenic Activity of Particulate
Matter Collected from
Urban Air
Yuka Ezoe,*, a Tadamichi Ohkubo,b
Kiyomi Ohmori,c Yuichi Fushiwaki,c
Yasuaki Mori,c Makoto Umeda,d
and Sumio Gotoa
aResearch Center for Material Cycles and Waste Management, National Institute for Environmental Studies, 16-2, Onogawa, Tsukuba, Ibaraki 305-8506, Japan, bNational Institute of Public Health, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8638, Japan, cKanagawa Prefectural Institute of Public Health, 1-3-1, Shimomachiya, Chigasaki, Kanagawa 253-0087, Japan, and dHatano Research Institute, Food and Drug Safety Center, 729-5 Ochiai, Hadano, Kanagawa 257-8523, Japan
Urban air particulate samples were collected on a quartz fiber filter with a High Volume Air Sampler, which was placed on the roof of the National Institute of Public Health, Minato-ku, Tokyo. Those samples were tested in both transformation assay using Bhas42 cells (Bhas assay) as a bioassay for cancer promoters and in the Ames microsuspension method as for initiators. Good dose-response relations were observed with both testing methods, and the samples showed mutagenicity and promoter activity. A comparison per particle weight between the samples collected in spring and autumn indicated that the value was higher in autumn samples, suggesting that mutagenic substances and cancer promoters might be polluting the air and be correlated with each other. Therefore, to monitor the carcinogenic-related activity of air pollutants, not only the mutagenicity assay but also bioassays for cancer promoters are required.
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