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J.Health Sci., 50(2), 164-168, 2004
Determination of Trace Levels of Elements in Urine by Inductively Coupled Plasma Mass Spectrometry
Junichi Nakagawa,*, a Yoshiteru Tsuchiya,b Yoshimori Yashima,c Masakatsu Tezuka,d
and Yasuo Fujimotod
aDepartment of Environmental Health, Tokyo Metropolitan Public Health Institute 3-24-1, Hyakunincho, Shinjuku-ku, Tokyo 169-0073, Japan, bCooperative Research and Development Center Yokohama National University 79-5, Tokiwadai, Hodogaya-ku Yokohama-shi, Kanagawa 240-8501, Japan, cThermo Electron kk C-2F, 3-9 Moriya-cho, Kanagawaku, Yokohama-shi, Kanagawa 221-0022, Japan, and dCollege of Pharmacy, Nihon University, 7-7-1, Narashinodai, Funabashi-shi, Chiba 274-8555, Japan
A biological specimen, urine, was prepared by the most simple sample preparation method, direct dilution, and determination of seven elements in the urine samples, Fe, Cu, Zn, Se, As, Cd, and Pb, was investigated by inductively coupled plasma mass spectrometry (ICP-MS). In addition, acid-decomposed samples were similarly investigated. Regarding the matrix effect of concomitant components, as the sodium hydrochloride concentration increased, the observed ion intensity of the measured element linearly decreased. Matrix interference by sodium hydrochloride could be fairly corrected by addition of internal standard elements excluding determination of Fe and Zn. On comparison of the measured values of samples prepared by direct dilution and acid-decomposition samples, the values were slightly lower in the samples prepared by direct dilution for many elements. For Zn and As, the analytical results of the human urine standard reference material were well consistent with the certified values.
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