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J.Health Sci., 50(2), 154-158, 2004
Role of Metallothionein in the Cell Cycle: Protection against the
Retardation of
Cell Proliferation by Endogenous
Reactive Oxygen Species
Yukihisa Takahashi, Yasumitsu Ogra, Kenji Ibata, and Kazuo T.
Suzuki*
Graduate School of Pharmaceutical Sciences, Chiba University,
1-8-1 Inohama, Chuo, Chiba 260-8675, Japan
The growth rate of metallothionein (MT)-null (MT-/-) cells was significantly lower than that of
wild-type (MT+/+) cells, the cell cycle being arrested
at the G2/M phase in MT-/- cells and endogenous
reactive oxygen species (ROS) accumulating with the
progress of the cell cycle. Exogenous ROS
generated on treatment with
H2O2 arrested the cell cycle
of MT-/- cells at the G2/M phase more severely than
that of MT+/+ cells. These observations suggest that
MT maintains the normal cell cycle as an
antioxidant against excessive endogenous ROS that are
generated synchronously with the cell cycle and disturb
the normal cell cycle.
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