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J.Health Sci., 50(2), 133-141, 2004
Investigation of Vasodilatory Substances in Diesel Exhaust Particles
(DEP): Isolation and Identification of Nitrophenol Derivatives
Shinji Taneda,*, a Kazuyuki
Kamata,b Hideyuki
Hayashi,b Noriko
Toda,a Koh-ichi
Seki,c
Akiyo Sakushima,d Shin
Yoshino,e Kouya
Yamaki,e Masakatsu
Sakata,b Yoki
Mori,b
and Akira K. Suzukia
aPM2.5/DEP Research Project, National Institute for
Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305-8506,
Japan, bFaculty of Pharmaceutical Sciences, Health Sciences
University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-0293,
Japan, cCentral Institute of Isotope Science, Graduate School of
Medicine, Hokkaido University, Kita-ku, Kita15, Nishi 7, Sapporo
060-0815, Japan, dFaculty of Pharmaceutical Sciences, Kyushu
University of Health and Welfare, 1714-1 Yoshino-machi,
Nobeoka, Miyazaki 882-8508, Japan, and
eKobe Pharmaceutical University, 4-19-1 Motoyamakita, Higashinada, Kobe
658-8558, Japan
Vasodilatory compounds in the weak acidic fraction of a benzene extract of diesel exhaust particles
(DEP) were fractionated by column chromatography
through silica gel, and the chemical structures of these
compounds were analyzed using GC-MS and
1H-NMR. The compounds in DEP that cause
vasodilation - 3- and 4-nitrophenol, 2-methyl-4-nitrophenol,
3-methy-4-nitrophenol, and 4-nitro-3-phenylphenol - were isolated and identified. All five of these
nitrophenols had vasodilatory activities
(10-4 to 10-6 M) in rat thoracic artery assays, and
4-nitro-3-phenylphenol was the most potent vasodilator among
these compounds. In addition, nine other alkylnitrophenols were isolated from the benzene
extract of DEP and characterized.
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